First, we reported the possible role for neutrophil extracellular traps on lung inflammation in COVID-19.6 Second, we found that the activation of NLRP3 inflammasome was associated with the severity of COVID-19 and poor clinical outcome.27 One of the actions of colchicine is to reduce migration of leucocytes, mainly neutrophils, to inflamed tissues.9 Whatever the mechanism of action—inhibiting inflammasome, reducing neutrophil migration and activation or preventing endothelial damage–colchicine seems to be beneficial for the treatment of hospitalised patients with COVID-19. The gene discussed is NLRP3; the disease is COVID-19.