This subgroup of macrophages is primed to secrete proinflammatory cytokines, such as IL-1β, IL-6 and TNF.23 Some groups found obesity a risk factor for severity of COVID-19, as reported in a systematic review with meta-analysis.24 Because of the small number of non-obese in our study population, we cannot simply extrapolate our findings to non-obese individuals of the general population, once the action of colchicine may be limited to those in which the association of obesity and inflammation has a pivotal pathophysiological effect. The gene discussed is TNF; the disease is COVID-19.