Furthermore, ERp57 overexpression in ALS mice led to the induction of Erbin, a regulator of synaptic transmission at the NMJ, and Myristoylated alanine-rich C-kinase substrate (Marcks), another protein involved in actin cytoskeleton control (Additional file 1: Fig. S6). This evidence concerns the gene PDIA3 and amyotrophic lateral sclerosis.