DOCK4 and Alzheimer disease: Finally, our results suggest that DOCK4 is the putative causal gene for the pleiotropic signal between DBP and AD at the DOCK4 locus, since the lead SNP is a low-frequency exonic variant in DOCK4 that is predicted to lead to exon 11 of DOCK4 being spliced out of the DOCK4 transcript (Fig. 3a).