APOE and Alzheimer disease: We identified a total of 39 independent loci that were bivariate genome-wide significant, met our AD-centric single-trait P value threshold of P value < 1 × 10− 6 and a cardiometabolic trait P value < 5 × 10− 3, and were outside of the HLA and APOE regions (Additional file 1 Supplementary Table 2).