Out of the genes identified by SNP, SPRY1/ANKRD50 and SLC7A11/PCDH18 genes in chromosome 4 which are located approximately 70 million base pairs from AMBN (Ameloblastin) and IL2RB gene in chromosome 22, which are located about 11 million base pairs from (Tuftelin interacting protein 11) TFIP11 are involved in the development of dental caries in children with asthma. The gene discussed is SPRY1; the disease is dental caries.