WWC1 and head and neck squamous cell carcinoma: It has been shown that ACTL6A interacts with tumor protein p63 (TP63) to repress WW and C2 domain containing 1 (WWC1), which is the regulator of the Hippo/yes associated protein (YAP) pathway, and ultimately contributes to regenerative proliferation and poor prognosis of head and neck squamous cell carcinoma [23].