In the PFC, L. edodes β-glucan could inhibit the proliferation of microglia (P < 0.01, Fig. 5b) and downregulate the expression of proinflammatory cytokines (TNF-α, IL-6, IL-1β) induced by the HF diet (all P < 0.05, Fig. 5c). Here, IL6 is linked to hydrops fetalis.