The genes repressed in both GE1-HCC and GE2-HCC included those with supposed tumour-inhibiting activity, e.g. CXCL14, CCBE1, IGFBP1, RND3, BMP10 and COLEC10, which encode proteins involved in extracellular matrix remodelling, migration and the immune response. This evidence concerns the gene RND3 and neoplasm.