EDC4 and hepatocellular carcinoma: A bioinformatic search for potential transcription factor binding sites (TFBSs) using the MATCHTM tool and TRANSFAC® library of positional weight matrices integrated in the GeneXplain platform identified a number of transcription factors potentially involved in the coordinated regulation of gene expression in the GE1-HCC and GE2-HCC subgroups (Additional files 15–18).