Notably, we found the genomic loci coding for H19 (11p15.5), RECQL4 (8q24.3), E2F1 (20q11.2), BIRC5 (17q25.3) and C1orf35 (1q42.13) to be frequently amplified in both GE1-HCC and GE2-HCC. The gene discussed is RECQL4; the disease is hepatocellular carcinoma.