In GE2-HCC, top potential transcriptional activators included transcription factors with reported tumour-promoting activity in HCC and/or other cancer types, e.g., NKX6-1, POU2F1/2, cJUN, E2F1, HSF2, SRF, TFCP2 and NFY (Table 8). The gene discussed is E2F1; the disease is cancer.