All aforementioned genes, i.e. CCNB2, PKMYT, some components of the APC/C complex (e.g. ANAPC1 and ANAPC11), CDC20, UBE2C, E2F1 and many others involved in progression and control of G2/M phase, were strongly upregulated in GE2-HCC. The gene discussed is E2F1; the disease is hepatocellular carcinoma.