Among these replicated genes, GPX3, TNIP1, MOB3B, C9orf72, SCFD1, SARM1, and UNC13A have been described as risk genes for ALS by earlier GWAS, while the others were novel risk genes, including C12orf56, G2E3, TRIP11, and GGNBP2. The gene discussed is MOB3B; the disease is amyotrophic lateral sclerosis.