Among these replicated genes, GPX3, TNIP1, MOB3B, C9orf72, SCFD1, SARM1, and UNC13A have been described as risk genes for ALS by earlier GWAS, while the others were novel risk genes, including C12orf56, G2E3, TRIP11, and GGNBP2. Here, GPX3 is linked to amyotrophic lateral sclerosis.