In this study, we aimed to determine the allele frequency and genotype distribution of CYP2C9 and AGTR1, and explore the relationships between hypertension and combined genotypes and phenotypes of CYP2C9 (CYP2C9*3, Ile359Leu, rs1057910, A1075C) and AGTR1 (rs5186, A1166C) in Han Chinese population using angiotensin II receptor antagonist. Here, AGTR1 is linked to Hypertension.