Besides, emerging studies revealed that HMGB1 was elevated in induced sputum and plasma in asthmatic patients, and that measures to inhibit HMGB1 were helpful to alleviate airway inflammation in ovalbumin(OVA)-induced asthma model (Watanabe et al. 2011; Shang et al. 2020). Here, HMGB1 is linked to asthma.