These genes include microglial marker genes, such as TMEM119 [17,18,19] and several genes involved in the pathogenesis of CNS disorders such as AD (CD33, CX3CR1, and TREM2) and hereditary diffuse leukoencephalopathy (CSF1R) [4,20,21,22,23,24]. The gene discussed is CX3CR1; the disease is Alzheimer disease.