RYR2 and catecholaminergic polymorphic ventricular tachycardia: Other conditions include Brugada syndrome, where over 350 pathogenic mutations were found in the SCN5A (18–30%) [29] and a dozen other genes (though 65% of cases do not have a genetic origin) [30], and catecholaminergic polymorphic ventricular tachycardia (CPVT), affected by RyR2 [31,32].