These include STK11 (serine/threonine kinase 11; mutation is also referred to as Peutz–Jeghers syndrome) [33], PTEN (phosphatase and tensin homolog; mutation is referred to as Hamartoma-tumor syndrome) [34], TP53 (Li–Fraumeni syndrome) [35], or E-cadherin 1 (CHD1; mutation predisposes its carrier to hereditary diffuse gastric cancer with increased risk of lobular breast carcinoma) [36] and genes with moderate penetrance such as CHEK2, BRIP-1, PALB2 or ATM (reviewed in Shiovitz and Korde, 2015 [37]). Here, PTEN is linked to breast lobular carcinoma.