BRCA2 and breast neoplasm: Additionally, others observed that distinct patterns of genomic alterations were associated with BRCA1- and BRCA2-deficient breast tumors and revealed elevated levels of large rearrangements and tandem duplications in BRCA1-deficient tumors, and increased SNVs and indels with microhomology in BRCA2-deficient tumors (Figure 2) [128,129].