Features of genomic instability of BRCA1/2-deficient cancers including increased mutation burden were showed also by Wen et al. However, they showed that only BRCA1-deficient tumors were associated with increased expression of PD-L1 and PD-1 together with higher abundance of tumor-infiltrating immune cells, and enrichment of T cell-inflamed signature [125]. The gene discussed is CD274; the disease is cancer.