The increase in the activity and expression of NOX2 in patients with AD was observed in tissues taken postmortem, showing the translocation of the subunits (p47phox and p67phox) towards the membrane, since this form would be indicative of NADPH oxidase activation in AD, principally for NOX2 which carries out this mechanism of activation [48]. The gene discussed is FMO5; the disease is Alzheimer disease.