Therefore, NOX activation can be mediated by several inflammatory factors, such as Aβ, tumor necrosis factor-alpha (TNF-α), interleukins and α-synucleins, proteins also involved in AD pathology, and the activation of microglial cells and NOX can produce more inflammatory mediators, causing a vicious circle which damages the neurons and causes neuron death [100,101]. This evidence concerns the gene TNF and Alzheimer disease.