In 2008, the SHARP trial established sorafenib, which simultaneously inhibits tumor growth by targeting the Raf-MEK-ERK cascade as well as angiogenesis by targeting vascular endothelial growth factor (VEGFR) 2, platelet-derived growth factor receptors (PDGFR), and KIT as a novel treatment in patients with advanced HCC [8]. Here, VEGFA is linked to neoplasm.