STAT3 and colorectal carcinoma: Co-culturing experiments revealed an 18% reduction (p < 0.0001) in myotubes exposed to MC38 CRC cells, while Western blotting demonstrated a nearly 5-fold increase (p < 0.0001) in STAT3 phosphorylation, a signaling pathway strongly implicated in muscle wasting in CRC-induced cachexia (Figure 7A–C) [9,12,13,17,18,19].