In addition to patient and clinical factors (e.g., functional status, comorbidities, and patient preferences), the therapeutic strategy is highly dependent on histological parameters (e.g., type of neoplasm, grade/differentiation, mitotic rate/Ki 67%, and other unique histological markers of response to certain therapies such as HER2/neu expression), anatomy/location, and, most importantly, the stage of the tumor [23,24]. The gene discussed is ERBB2; the disease is neoplasm.