Intravenous administration of t-PA@iRNP (t-PA; 0.04mM and iRNP; 5.3 mM TEMPO, five times with interval of three days) to mouse xenograft model of C-26 colon cancer cell line, showed effective suppression of tumor growth as compared to control, t-PA@niRNP (no antioxidant capacity), naked t-PA, and iRNP, validating the synergistic effect of iRNP and t-PA (Figure 7c) [112]. Here, PLAT is linked to malignant colon neoplasm.