Similarly, Gokulakrishnan et al., [45] concluded that TNF-alpha concentration correlates to Body Mass Index (BMI) and impaired glucose metabolism and, even more, they found that pro-inflammatory markers, CRP and TNF-alpha, demonstrate a cumulative effect on atherosclerotic changes in patients with obesity and normal glucoregulation. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.