A meta-analysis of 16 observational studies by Shelton et al., including 11,702 cases, explored the risk of cancer recurrence among patients affected by immune-mediated diseases (IBD, rheumatic disease and psoriasis) and treated with thiopurines, methotrexate, anti TNF-alpha or a combination of them (anti TNF-alpha plus immunomodulator). The gene discussed is TNF; the disease is inflammatory bowel disease.