CXCL8 and acne: It should be noted that C. acnes biofilms are more frequently observed in patients with acne [153,154] where the biofilm contains several proteins, including CAMP1 implicated in inflammation [155,156] and the miR-146a miRNA, which downregulates the production of pro-inflammatory compounds, such as IL-6, IL-8, and TNF-α in keratinocytes [157].