HMGB1 and neoplasm: Indeed, while ferroptotic cancer cells could secrete a number of danger signals (AA metabolites and HMGB1) that foster anti-tumor immunity through lymphocyte recruitment and APC activation, both cancer and tumor-infiltrating immune cells (which could eventually undergo ferroptosis) could (at the same time) release immunosuppressive molecules such as PGE2 or overexpress immune checkpoints ligands to promote immune-escape [151].