However, the OR for the risk of overweight/obesity was almost six times higher in the highest rate of change of fat intake (Q3 > 1.11) than in the lowest one (Q1 < 0.8) in the minor alleles of two MEK6 SNPs (rs9916229 (6.37, CI;1.47~27.58) and rs756942 (6.25, CI;1.44~27.05)). Here, MAP2K6 is linked to obesity due to melanocortin 4 receptor deficiency.