To investigate the relationship between the serum GP73 and TBA levels in liver disease, the serum GP73 and TBA levels were analyzed in a total of 4211 patients, including 985 non-cirrhotic CLD patients, 2141 liver cirrhosis patients, and 1085 HCC patients (Figure S1, Supplementary Materials). This evidence concerns the gene GOLM1 and hepatocellular carcinoma.