The downregulation of the PI3K/Akt pathway and NF-ĸB leads to changes in various related genes, NF-ĸB p65, GSK3B, XIAP, Bcl-2, VEGF, COX-2, PGE2, inducing apoptosis and inhibiting metastasis in cancer cells [130,131,132]. Here, XIAP is linked to cancer.