TP53 and osteosarcoma: TQ upregulating effect on the proapoptotic transcription factor, p53, was clearly emphasized in numerous in vitro and in vivo studies on cancer models, where TQ induced apoptosis through the upregulation of p53 in breast cancer [64,65,66], renal cell carcinoma [67], leukemia [68], glioblastoma [69,70], squamous cell carcinoma [71], cervical cancer [72], lung cancer [73], and osteosarcoma [74].