Furthermore, in renal cancer cells, ERβ could modulate HOTAIR, and consequently antagonize, in addition to miR-217, other miRNAs (miR-200c, miR-138, miR-204) to upregulate specific oncogenes, such as metalloproteinase domain 9 (ADAM9), cyclin D2 (CCND2), EZH2, VEGFA, vimentin (VIM), and zinc finger E-box binding homeobox 1 and 2 (ZEB1 and ZEB2), to promote RCC proliferation and invasion [131]. The gene discussed is CCND2; the disease is renal carcinoma.