HOTAIR silencing in glioma cells leads to upregulation of miR-326 expression and it is able to suppress tumor growth and prolong the survival of nude mice, downregulating FGF1, p-PI3K/PI3K, p-AKT/AKT, and p-MEK1/2/MEK1/2 expression [141]. The gene discussed is MAP2K1; the disease is glioma.