DMD and neuromuscular disease caused by qualitative or quantitative defects of dystrophin: Detailed reviews have been published on the composition of the core dystrophin complex [19,56,57,58], as well as the role of dystrophin and its associated glycoprotein complex in the multisystemic complications of dystrophinopathy and pathophysiological crosstalk throughout the body [34,35,36,37,59].