Thus, although one study in mice postulated that IL-6 gene expression deficiency did not have any effect in prion pathogenesis [79], we strongly support the idea that this neuromodulator peptide is relevant to prion disease pathogenesis [3,9,10,11,12,13,14,15], as has been described for prion-like diseases [80,81,82]. Here, IL6 is linked to prion disease.