TNF and prion disease: A great number of suggestions have led to hypotheses about the existence of a mixed inflammatory profile in prion diseases contributing to immune response [35,36,37]; on the one hand, some studies described a limited pro-inflammatory response, with no increases in IL-1 and TNF [18,22,38,39]; on the other hand, some others described increases of some factors, these same cytokines among them [9,10,15].