This differential blockade of TNFα isoforms is critical for activating the immune system in cancer patients, since it is known that the tmTNFα–TNFR2 interaction is necessary for the crosstalk between DC and NK cells, which does not depend on the sTNFα-TNFR1 axis [200,201,202]. This evidence concerns the gene TNFRSF1B and cancer.