It has been shown that minimizing the amount of TNFα targeting the vascular endothelium with Cys-Asn-Gly-Arg-Cys-Gly-TNFα (NGR-TNF), a fusion protein targeting the tumor vasculature [147], can activate the endothelial cells and enhance tumor infiltration by cytotoxic T lymphocytes [268]. This evidence concerns the gene TNF and neoplasm.