PDCD1 and melanoma: The RNA of different melanoma cell lines treated with TNFα was also sequenced, and it was seen that the pathways of dedifferentiation induced by inflammation may overlap with those of innate resistance to anti-PD-1 gene signature [288], which includes genes related to EMT transition, hypoxia, and angiogenesis, and suggests that dedifferentiation may reflect a more invasive phenotype.