CTLA4 and cancer: The impressive clinical impact of these antibodies in the oncology arena was recognized by the 2018 Nobel Prize in Physiology or Medicine awarded to Dr. James Allison (MD Anderson Cancer Center at the University of Texas, Houston, TX, USA) and Dr. Tasuku Honjo (Kyoto University, Kyoto, Japan), for their contributions to the research on CTLA-4 and PD-1, respectively [239].