In ovarian cancer cell lines HO8910 and SKOV3, it was demonstrated that TAMs or cytokines released from them, like IFN-γ, TNFα, IL-10, and IL-6, are responsible for the upregulation of PD-L1 expression in the surface of these cells, but no modification in its mRNA was observed. The gene discussed is TNF; the disease is ovarian carcinoma.