TNFα antitumor mechanisms are varied and include the following: mediating cellular apoptosis extensively reviewed by Rath et al. [51]; directing tumor-associated macrophages (TAMs) to the M1 profile (antitumoral phenotype) [52]; guiding neutrophils and monocytes to tumor sites [53,54], activating macrophages and inhibiting monocyte differentiation to immunosuppressive phenotypes [55]; and inducing disruption of tumor vasculature [56,57]. Here, TNF is linked to neoplasm.