TGFB1 and neoplasm: These components include secreted factors from tumor cells (VEGF, PIGF, S100A8/A9, etc.), bone marrow-derived cells (VLA-4, Id3), suppressive immune cells (HSF1, girdin, fibronectin, etc.), host stromal cells (TGF-β, TNF-α, G-CSF, etc.)and/or delivered by extracellular vesicles (MIF, OPN, microRNA-122, etc.)[125].