EGFR and head and neck cancer: Although the advent of vaccination has represented a leap forward in achieving some of these goals, the burden of disease is still significant, and many affected individuals do not attain a so-called “cure.” Like other markers that are used in the context of head and neck cancers (e.g., Epstein-Barr virus (EBV), epidermal growth factor receptor (EGFR), HPV-related markers are advantageous in that they can be detected via non-invasive methodologies (namely, mouth, throat, and blood sampling).