Both mono‐EGF‐IT and bi‐EGF‐IT effectively inhibited Cal27 HNSCC cell growth with IC50 values of 8.75 × 10−11 m and 9.96 × 10−11 m for mono‐EGF‐IT and bi‐EGF‐IT, respectively (Fig. 2E). The gene discussed is EGF; the disease is head and neck squamous cell carcinoma.