In our previous study, we found that LDN can up-regulate the expression of CD83, CD80, CD40 and other molecules on the surface of bone marrow derived dendritic cells (BMDCs) in vitro, further promote the differentiation and maturation of BMDCs, promote the release of IL-12 and TNF-α, and indirectly kill tumor cells [29]. This evidence concerns the gene CD83 and neoplasm.