Several studies ascribe a crucial role in the pathogenesis of prion diseases and PrPC-PrPSc conversion to membrane attachment of PrP (6, 7, 8, 9, 10, 11, 12, 13), where contact between endogenous PrPC and exogenous PrPSc can easily occur and membrane properties can impact protein structure and function. The gene discussed is PRNP; the disease is prion disease.