Consistently, our RNA-seq analysis reveals a significant enrichment in the ovaries of PAMH F3 mice of genes involved in the negative regulation of insulin secretion, including Inhbb, Ide, Fst, and TGF-β signaling pathway, which also regulate folliculogenesis and ovarian steroidogenesis (Findlay, 1993; Liu et al., 2016) and which are affected in human PCOS ovarian tissues (Liu et al., 2016; Pan et al., 2018). The gene discussed is INS; the disease is polycystic ovary syndrome.