Taking into account the hypomethylation of two key DNA methylation related genes in PAMH F3 ovaries, Tet1 and Uhrf1, that could contribute to the preponderance of global DNA hypomethylation identified in PCOS-like mice, we first assessed the methylation levels of TET1 and UHRF1 in blood samples of women with PCOS and in healthy women. This evidence concerns the gene UHRF1 and polycystic ovary syndrome.