Given the strong heritability of PCOS and the well-documented transmission of the cardinal neuroendocrine and metabolic features observed in first degree relatives of PCOS women (Sir-Petermann et al., 2002, 2012), we sought to test whether female PCOS-like offspring (F1) of gestating mice prenatally exposed to high AMH (F0) (Tata et al., 2018) are susceptible to transfer PCOS-like traits to F2 (intergenerational) and to F3 (transgenerational) offspring. The gene discussed is AMH; the disease is polycystic ovary syndrome.