As the BMI of women with PCOS included in this investigation is not significantly different compared with controls, both in unrelated women and in CNTR-D and PCOS-D (Tables S2 and S3), and because several metabolic parameters (fasting insulin, fasting glycemia, and triglycerides) are within the normal range in the PCOS groups, we can exclude a priori the contribution of metabolic alterations on the differential methylation landscape of women with PCOS versus control women. This evidence concerns the gene INS and polycystic ovary syndrome.