This animal model, named PAMH, recapitulates all the diagnostic criteria for PCOS in women, including hyperandrogenism, oligo-anovulation, altered fertility, together with increased gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion, which exacerbate the hyperandrogenism in mice (Tata et al., 2018) and humans (Stener-Victorin et al., 2020; Walters et al., 2018). This evidence concerns the gene GNRH1 and hyperandrogenism.