We identified five (ROBO-1, CDKN1A, HDC, IGFBPL1, and IRS4) out of the six genes selected from the genome-wide methylation profile of the PAMH lineage as being also differentially methylated in blood samples of women with PCOS as compared with healthy women (Figure 7B). This evidence concerns the gene IGFBPL1 and polycystic ovary syndrome.