HDC and polycystic ovary syndrome: Similar to the methylation changes observed in the ovaries of PCOS-like animals, we found a trend for a hypomethylation in the locus of Tet1 (p = 0.07; Mann-Whitney test) and a significant hypomethylation in the locus of Hdc (p = 0.02; Mann-Whitney test) in the hypothalami of PAMH F3 animals as compared with controls (Figure 5C), whereas we did not detect any methylation changes in the other three genes of CNTR and PCOS animals (Figure 5C).