2013). Berberine was also found to inhibit LPS-induced cardiac dysfunction (Denk et al. 2012). Furthermore, berberine reduces the release of the cytokines TNF-α and IL-1β by inhibiting IκB in lung tissue cells (Lee et al. 2007). Berberine is also considered a potential anticancer drug for the treatment of endometrial cancer, as it suppresses growth and metastasis via miR-101 (Wang and Zhang 2018). Berberine also inhibits the activation and expression of transcription factor in sepsis by downregulating the NF-κB, Akt and MAPK/JNK/p38/ERK pathways (Gao et al. 2014). Here, TNF is linked to Sepsis.