After analysis of RNA‐Sequencing data sets of 20 LUAD and 20 LUSC samples from TCGA cohort, the results showed that EIF4G1 potentially up‐regulated inhibitory checkpoint molecules whereas down‐regulating stimulatory checkpoint molecules (Figure 2A‐B), which may facilitate tumour cell immune escape for both subtypes of NSCLC. This evidence concerns the gene EIF4G1 and neoplasm.