Although the EIF4F complex may control cellular protein translation, the protein array analyses indicated that only a limited number of proteins were significantly changed within EIF4G1 stably knockdown H1299 cell line when compared to the controls, which is partially because of the detectable capability of protein array (~500 targets), even though these data imply the existence of a unique protein signature controlled by EIF4G1 in NSCLC cells. The gene discussed is EIF4G1; the disease is non-small cell lung carcinoma.