When analysing Aβ isoforms generated by cerebral organoids, there was an increase in Aβ1‐19 and Aβ1‐34 relative to amyloidogenic species (Aβ1‐40 and Aβ1‐42) in Down's syndrome organoids when compared to isogenic diploid cells and APP duplication organoids. The gene discussed is APP; the disease is Down syndrome.