Kim et al. [60] and Song et al. [61] discovered that increases in plasma adiponectin of much as 1.0 μg/mL and 4.5 μg/ml were associated with a 6% reduction in hypertension prevalence and 38% to 63% lower odds of incident and persistent metabolic syndrome in the adult population, respectively. The gene discussed is ADIPOQ; the disease is hypertensive disorder.