ITGB1 and hereditary clear cell renal cell carcinoma: Furthermore, miR-134 is known as a tumor suppressor because it directly silences the KRAS oncogene as well as the integrin beta 1 (ITGB1) oncogene [18, 19], the activity of which genes also promotes malignant transformation and proliferation of malignant cells [20], which can lead to renal cell carcinoma (RCC) [21].