When the patients were evaluated according to the degree of pathology (IND and CCC), the greatest differences in the frequencies of CD4+ T cells expressing each inhibitory receptor under study were observed between CCC and HD, and the significance of the differences were as follows: 2B4 (p<0.0001), CD160 (p<0.01), CTLA-4 (p<0.0001), PD-1 (p<0.0001) and TIM-3 (p<0.01) (Fig 1A). The gene discussed is CTLA4; the disease is Huntington disease.