NR4A3 and cancer: IFI27 has been reported to be involved in different biological processes including the regulation of cellular apoptosis; modulation of the transcriptional activity of nuclear receptors NR4A1, NR4A2 and NR4A3; involvement in the ubiquitin-mediated proteasomal degradation pathway and playing antivirus functions[45–49], IFI27 has been shown to inhibit Heptatis C virus replication by through the activation of JAK/STAT signaling pathway[50], which has been reported to be interact with AKT and MAPK/ERK pathways and to be associated with cancer development[51,52].