However, ATF3 suppresses esophageal SCC growth by downregulating ID1 (inhibitor of DNA binding 1), blocks the metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton and inhibits the progression of hepatocellular carcinoma cells by upregulating CYR61 expression. The gene discussed is ID1; the disease is hepatocellular carcinoma.