IFI6, has been shown to play anti-apoptosis role in gastric cancer cells, breast cancer cells, human myeloma cells and vascular endothelia cells mainly through inhibiting activation of caspase 3 and suppressing proapoptotic gene BCL-2 expression[53–56], and anti-apoptosis plays a crucial role for tumor development. Here, CASP3 is linked to plasma cell myeloma.