To investigate whether IFI6 and/or IFI27 are direct targets of ATF3, we analyzed published ATF3 CHIP-seq data (http://cistrome.org) and found that both IFI6 and IFI27 are putative targets of ATF3 in several cell types, including colon cancer cells, liver epithelial cells, erythroblasts, embryonic stem cells and skin dermal fibroblasts [27–30]. Here, ATF3 is linked to colonic neoplasm.