ATF3 and neoplasm: Furthermore, suppression of TSCC growth by ATF3 was verified in an in vivo mouse model, which also showed that ATF3 could promote TSCC cell differentiation (Fig 6K–6N), agreed to GO analysis result of RNA-seq data (Fig 4A) and the induction of differentiation has been considered to be an anti-tumor function of ATF3 [42].