Features of obesity-induced metabolic and inflammatory diseases include accumulation of ectopic fat in key insulin-sensitive organs, inflammation of white adipose tissue (AT), and infiltration of proinflammatory macrophages, all contributing to the development of insulin resistance, type 2 diabetes (T2D), cardiovascular and neurodegenerative diseases, and cancer (1). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.