In addition, the patients were stratified according to their initial CD4+ cell count to allow for a clinically oriented classification: Patients with a CD4+ cell count > 350 cells/μl (n = 55), who had a good or only moderately compromised immune status, and patients with a more pronounced immune deficiency, the so-called late presenters with a CD4+ cell count < 350 cells/μl. The gene discussed is CD4; the disease is Immunodeficiency.