Likewise, a substitution in GCAP1 that also causes a dominant retinopathy, Gly86Arg, not only shifts the Ca2+ sensitivity of RetGC deceleration to a higher Ca2+ range, but also makes RetGC better resist the inhibition by RD3, again, most likely because of the increased affinity of the Gly86Arg GCAP1 for RetGC1 [96]. The gene discussed is GUCY2D; the disease is retinal disorder.