For example, IPEX syndrome (analogous to murine scurfy syndrome [3]) results from different mutations across the FOXP3 gene [133], showing that Tregs are indispensable to prevent T1D (even perinatally), inflammatory bowel disease and allergies, although the clinical variability of IPEX correlates poorly with the type of FOXP3 mutation [134]. Here, FOXP3 is linked to type 1 diabetes mellitus.