Both serum CRP level (117.6 ± 88.1 vs. 78.5 ± 75.2, P = 0.017) and IL-6 level (133.5 ± 149.2 vs. 69.9 ± 100.0, P = 0.021) of severe influenza patients with aspergillosis were greatly higher than those without aspergillosis. The gene discussed is IL6; the disease is aspergillosis.