According to the hazard ratio for the prognosis of risk variables for COVID-19, the admission classification (severe or critically severe), age over 65 years old, levels of Fer over 907.4 ng/ml, PCT over 0.795 ng/ml, D2 over 8.175 μg/ml, CRP over 102.8 mg/L, CEA over 33.45 ng/ml (excluding tumors), a WBC count over 13.76 × 109/L, Neu% over 92.6%, and L% below 4.2% were higher risk factors for poor patient OS. This evidence concerns the gene CRP and COVID-19.