Most importantly, loss of function of Tet2 in mice results in abnormal DNA hydroxymethylation patterns in bone marrow cells and leads to the emergence of myeloid malignancies between 2 and 4 months of age (Li et al., 2011; Moran-Crusio et al., 2011; Quivoron et al., 2011; Mulholland et al., 2020a). This evidence concerns the gene TET2 and myeloid neoplasm.