Although we have found that otub1 promoted the proliferation and progression of PCa via mediating and stabling Cyclin E1, in which one ubiquitination enzyme directly causing to the ubiquitination degradation of Cyclin E1 remains unclear, and the manner of OTUB1 regulating the expression of Cyclin E1 directly or indirectly are still yet not determined. Here, CCNE1 is linked to posterior cortical atrophy.