OTUB1 and neoplasm: For example, OTUB1 is found to be up-regulated in colorectal cancer (Zhou et al., 2014), gastric adenocarcinoma (Weng et al., 2016), esophageal cancer (Sun et al., 2020), ovarian cancer (Wang et al., 2016), human glioma (Xu et al., 2017), and hepatocellular carcinoma (Ni et al., 2017), which could promote tumor invasion and predict a poor prognosis.