Based on these findings of previous studies, OTUB1 promotes the metastasis of esophageal squamous cell carcinoma by modulating snail stability (Zhou et al., 2018), while different expression of OTUB1 affects the migration and progression of colorectal cancer through the regulation of ERRα or mir-542-3p (Yuan et al., 2017; Zhou et al., 2019). Here, SNAI1 is linked to colorectal cancer.